Professor Dez Kyte

Derek Kyte (resized)

Professor of Physiotherapy

School of Health and Wellbeing

Department of Allied Health

Contact Details

email: d.kyte@worc.ac.uk

Prof Kyte trained as a Physiotherapist at the University of Bradford, graduating in 1996. He went on to work in the NHS for over 10 years, rising to a position as an Extended Scope Practitioner (Trauma & Orthopaedics) at the Sandwell and West Birmingham Hospitals NHS Trust. He moved into academia as a Clinical Tutor at the University of Birmingham in 2007. In this role he was involved in the delivery of under- and post-graduate education within the department of nursing and physiotherapy, specialising in anatomy & physiology and musculoskeletal practice. He completed an MSc in Advancing Practice (Specialist Manipulative Physiotherapy) in 2009. In 2011, he successfully applied for a fully funded NIHR doctoral fellowship, completing the PhD alongside his physiotherapy teaching workload and graduating in 2015.

Qualifications

  • 2019 - PGCert Academic Practice, University of Birmingham, UK
  • 2015 - PhD, University of Birmingham, UK 
  • 2009 - MSc, University of Birmingham, UK 
  • 1996 - BSc (Hons), Physiotherapy, University of Bradford, UK   

Teaching Interests

Prof Kyte has a Higher Education Academy Fellowship and has been involved in research-informed learning & teaching activity across a number of under- and post-graduate health-focused programmes, including: physiotherapy [BSc(Hons); MSc (pre-registration); MSc (Advancing Practice)], Medicine [Bachelor of Medicine and Surgery (MBChB), Bachelor of Medical Sciences (BMedSci) Population Sciences and Humanities], Public Health [MPH] and Clinical Trials [MSc]. He employs a variety of learning and teaching methods (e.g. Inquiry-based learning, Kinesthetic Learning, Flipped Classrooms etc), including digital methods to support blended learning, and completed a PgCert in Academic Practice at the University of Birmingham in 2019.

Research Interests

Prof Kyte's primary research interests centre around health outcomes and remote symptom monitoring in the NHS. In particular, the use of patient-reported outcomes (PROs) across a range of conditions and clinical areas including chronic kidney disease, cancer and musculoskeletal care. He leads the Living with Long-Term Conditions Research Group at the University of Worcester.

Prof Kyte has a h-index of 30 and has published 76 papers in peer-reviewed journals including: Physiotherapy (Impact Factor 3.010); Manual Therapy (Impact Factor 2.158); the BMJ (Impact Factor 30.223), Journal of the American Medical association (Impact Factor 45.540), PLOS Medicine (Impact Factor 10.500), Journal of the National Cancer Institute (Impact Factor 12.589) and the Lancet (Impact Factor 60.392) and he has a current total grant income >£3 million. His work has informed the European Medicines Agencies guidelines on the evaluation of anticancer medicinal products in man and is REF returnable.

Prof Kyte is an active member of the International Society for Quality of Life Research (ISOQOL) and Centre for Patient-Reported Outcomes Research (CPROR) at the University of Birmingham. He is a former chair of the UK National Cancer Research Institute (NCRI) Living with and Beyond Cancer Methodology Workstream.

Awards

  • The University of Birmingham Founders’ Award for Outstanding Early-Career Academic, 2017.
  • Best patient and public involvement team award, UK national PROMs conference, University of Birmingham, UK, 2018.
  • Outstanding oral presentation award at the International Society for Quality of Life Research (ISOQOL) 25thAnnual Conference, Dublin, IRE, 2018.
  • Outstanding poster award, International Society for Quality of Life Research (ISOQOL) 24rd Annual Conference, Philadelphia, USA, 2017.
  • MPHrp Team Award - Fourth NIHR Infrastructure Experimental Medicine Research Training Camp, 2013. 

Research grants and awards received [selected]

Successful grant applications = 24; total grant income >£3 million.

  1. NIHR RfPB Competition 43 Stage 2 - West Midlands: “A pilot study to assess the safety, effectiveness and, practical utility of remote patient monitoring to guide the timing of valve intervention in patients with asymptomatic severe aortic stenosis (APRAISE-AS)”. £249,540.00. Co-I.
  2. Development of a disease-specific item bank and multidimensional computerized adaptive test (MCAT) to measure health-related quality of life and symptom burden in patients with chronic kidney disease. Kidney Research UK £176,622.07. PI.
  3. Calvert M, Kyte D, Price G. PROmics – value proposition, route to market and business model, Enterprising Birmingham Fund Award, £9,960. Feb 19-Apr 19. Co-I.
  4. Kaur G, Calvert M, Kyte D, Kearns P. Conduct qualitative interviews to inform study design and methods for fellowship proposal. Wellcome Trust ISSF: Digital Health Pilot Grant, £4,454. Feb 19-Jun 19. Co-I.
  5. Anderson N, Kyte D, Dutton M, Cockwell P, Calvert M. (2019-22) Using electronic Patient-Reported Outcome Measures (ePROMs) to promote quality of care and safety in the management of patients with End Stage Kidney Disease requiring treatment with Haemodialysis (HD) in research and routine clinical settings: a mixed-methods study. NIHR CDRF. £258,821.06. Co-I.
  6. Newsome P, Calvert M, Kyte D, Price P, Harding R, Dunster H, Gostick N, Dignio Ltd. Patient-reported outcomes assessment to support accelerated access to advanced cell and gene therapies: PROmics. Innovate UK, £1,189,402 Dec 18-Mar 21. Co-I.
  7. Calvert M, Kyte D, Price G, Dunster H, Gostick N, Harding R, Ball S, Dahle L, Garner K. PROmics Accelerated access to new medicines – promoting patient safety and quality of life. Medical Research Council (MRC) Proximity to Discovery (PtD), £9,946, Sep 18-Feb 19. Co-I.
  8. NIHR Biomedical Research Centre (BRC) - Core Theme. £109,802.00. Co-I.
  9. Kyte D. Feasibility Study for a Randomised Controlled Trial of electronic Patient-Reported Outcome Measure (ePROM) Use in the Management of Patients with Advanced Chronic Kidney Disease (e-PROM CKD) £537,221 NIHR PDF Jan2017-Dec2020. PI

Membership of Professional Bodies

  • 2019 - Fellow of the Higher Education Academy (FHEA) 
  • 2012 - Member of the International Society for Quality of Life
  • 2008 - Member of the Musculoskeletal Association of Chartered Physiotherapist Research
  • 1996 - Member of the Health and Care Professions Council
  • 1996 - Member of the Chartered Society of Physiotherapy              

PhD Opportunities

Prof Kyte has supervised 4 doctoral students to completion. He has a track record of supporting doctoral students to secure research funding to underpin their work. In addition, he is passionate about supporting his students to disseminate their findings both nationally and internationally, through high-impact publications and conference presentations. In 2018, a former PhD student, Dr Cruz-Rivera, was awarded the University of Birmingham Michael K. O'Rourke Best Publication prize. The paper, published in PLOS Medicine in 2017 has been viewed over 50,000 times and has been cited in 100 peer-reviewed publications.

 

Current PhD Opportunities

  • Routine Monitoring of Depression and Anxiety in Patients with Chronic Kidney Disease (CKD).
  • Clinical Significance and Diagnostic Accuracy of Special tests in Rotator Cuff Related Shoulder Pain.

 

Former PhD Students

  • Birgith Englest Grove. Remote symptom monitoring using patient-reported outcome (PRO) measures in patients with chronic kidney disease: The PROKID study. Aarhus University, Aarhus, Denmark, 2023.
  • Nicola Anderson. Using patient reported outcome measures (PROMs) to promote quality of care and safety in the management of patients with established kidney disease requiring treatment with haemodialysis. University of Birmingham, UK, 2023.
  • Samantha Cruz Rivera. Evaluating the impact of patient-reported outcome [PRO] trial results on future patient care. University of Birmingham, UK, 2019.
  • Olalekan Lee Aiyegbusi. Using patient-reported outcome measures (PROMs) to promote quality of care and safety in the management of patients with advanced chronic kidney disease. University of Birmingham, UK, 2019.

Recent Publications

76 publications, h-index of 30, i10-index 55, 3478 citations

  1. Development and usability testing of an electronic patient-reported outcome (ePRO) solution for patients with inflammatory diseases in an Advanced Therapy Medicinal Product (ATMP) basket trial Christel McMullan; Ameeta Retzer; Sarah E. Hughes; Olalekan Lee Aiyegbusi; Camilla Bathurst; Alan Boyd; Jamie Coleman; Elin Haf Davies; Alastair K Denniston; Helen Dunster; Chris Frost; Rosie Harding; Amanda Hunn; Derek Kyte; Rebecca Malpass; Gary McNamara; Sandra Mitchell; Saloni Mittal; Philip N Newsome; Gary Price; Anna Rowe; Wilma van Reil; Anita Walker; Roger Wilson; Melanie Calvert. Journal of Patient-Reported Outcomes (2023).
  2. Van der Veer SN, Kyte D, Chadwick H, Cockwell P, Ercia A, Gair R, Finnigan R, Fraser SD, Knowles S, and Sharma S Putting patients at the centre: including patients’ perspective into UK kidney care and research. A roadmap for collecting electronic patient-reported outcome measures (ePROMs) [Internet]. 2023. Available from: https://doi.org/10.48420/21916518
  3. Global Use of Electronic Patient-Reported Outcome Systems in Nephrology: A Mixed-Methods Study. BMJ Open (2023).
  4. Anderson, N., Kyte, D., McMullan, C. et al.Electronic patient-reported outcomes in chronic kidney disease. Nat Rev Nephrol (2022). https://doi.org/10.1038/s41581-022-00619-3
  5. Brundage MD, Crossnohere NL, O'Donnell J, Cruz Rivera S, Wilson R, Wu AW, David M, Kyte D, Reeve BB, Gilbert A, Chen RC, Calvert MJ, Snyder C. Listening to the patient voice adds value to cancer clinical trials. J Natl Cancer Inst. 2022 Jul 28:djac128. doi: 10.1093/jnci/djac128. Epub ahead of print. PMID: 35900186.
  6. Fletcher BR, Damery S, Aiyegbusi OL, Anderson N, Calvert M, Cockwell P… Kyte D et al. (2022) Symptom burden and health-related quality of life in chronic kidney disease: A global systematic review and meta-analysis. PLoS Med 19(4): e1003954.
  7. Kyte D, Anderson N, Bishop J, Bissell A, Brettell E, Calvert M, Chadburn M, Cockwell P, Dutton M, Eddington H, Forster E, Hadley G, Ives NJ, Jackson LJ, O'Brien S, Price G, Sharpe K, Stringer S, Verdi R, Waters J, Wilcockson A. Results of a pilot feasibility randomised controlled trial exploring the use of an electronic patient-reported outcome measure in the management of UK patients with advanced chronic kidney disease. BMJ Open. 2022 Mar 18;12(3):e050610. doi: 10.1136/bmjopen-2021-050610. PMID: 35304391.
  8. Bhachu H, Fenton A, Cockwell P, Aiyegbusi O, Kyte D, Calvert M. Use of the kidney failure risk equation to inform clinical care of patients with chronic kidney disease: a mixed-methods systematic review. BMJ Open. 2022 (in press).
  9. Grove BE, Schougaard LMV, Ivarsen PR, Kyte D, Hjollund NH, de Thurah A. Patient-reported outcome measures for clinical decision-making in outpatient follow-up: validity and reliability of a renal disease questionnaire. J Patient Rep Outcomes. 2021 Oct 16;5(1):107. doi: 10.1186/s41687-021-00384-0. PMID: 34655365; PMCID: PMC8520563.
  10. Anderson NE, McMullan C, Calvert M, Dutton M, Cockwell P, Aiyegbusi OL, Kyte D. Using patient-reported outcome measures during the management of patients with end-stage kidney disease requiring treatment with haemodialysis (PROM-HD): a qualitative study. BMJ Open. 2021 Aug 26;11(8):e052629. doi: 10.1136/bmjopen-2021-052629. PMID: 34446501; PMCID: PMC8395280.
  11. Bhachu HK, Cockwell P, Subramanian A, Adderley NJ, Gokhale K, Fenton A, Kyte D, Nirantharakumar K, Calvert M. Impact of Using Risk-Based Stratification on Referral of Patients With Chronic Kidney Disease From Primary Care to Specialist Care in the United Kingdom. Kidney Int Rep. 2021 Jun 1;6(8):2189-2199. doi: 10.1016/j.ekir.2021.05.031. PMID: 34386668; PMCID: PMC8343777.
  12. Miller C, Cross J, O'Sullivan J, Power DM, Kyte D, Jerosch-Herold C. Developing a core outcome set for traumatic brachial plexus injuries: a systematic review of outcomes. BMJ Open. 2021 Jul 30;11(7):e044797. doi: 10.1136/bmjopen-2020-044797. PMID: 34330851.
  13. Snyder C, Gilbert A, Moher D, Kyte D, Daniels E, King M, Calvert M, Chen RC, Brundage M; PROTEUS consortium. Recommendations for including or reviewing patient reported outcome endpoints in grant applications. BMJ. 2021 Jun 30;373:n1367. doi: 10.1136/bmj.n1367. PMID: 34193444.
  14. Calvert M, King M, Mercieca-Bebber R, Aiyegbusi O, Kyte D, Slade A, Chan AW, Basch E, Bell J, Bennett A, Bhatnagar V, Blazeby J, Bottomley A, Brown J, Brundage M, Campbell L, Cappelleri JC, Draper H, Dueck AC, Ells C, Frank L, Golub RM, Griebsch I, Haywood K, Hunn A, King-Kallimanis B, Martin L, Mitchell S, Morel T, Nelson L, Norquist J, O'Connor D, Palmer M, Patrick D, Price G, Regnault A, Retzer A, Revicki D, Scott J, Stephens R, Turner G, Valakas A, Velikova G, von Hildebrand M, Walker A, Wenzel L. SPIRIT-PRO Extension explanation and elaboration: guidelines for inclusion of patient-reported outcomes in protocols of clinical trials. BMJ Open. 2021 Jun 30;11(6):e045105. doi: 10.1136/bmjopen-2020-045105. PMID: 34193486.
  15. Slade AL, Retzer A, Ahmed K, Kyte D, Keeley T, Armes J, Brown JM, Calman L, Gavin A, Glaser AW, Greenfield DM, Lanceley A, Taylor RM, Velikova G, Turner G, Calvert MJ. Systematic review of the use of translated patient-reported outcome measures in cancer trials. Trials. 2021 Apr 26;22(1):306. doi: 10.1186/s13063-021-05255-z. PMID: 33902699; PMCID: PMC8074490.
  16. Giesinger JM, Efficace F, Aaronson N, Calvert M, Kyte D, Cottone F, Cella D, Gamper EM. Past and Current Practice of Patient-Reported Outcome Measurement in Randomized Cancer Clinical Trials: A Systematic Review. Value Health. 2021 Apr;24(4):585-591. doi: 10.1016/j.jval.2020.11.004. Epub 2021 Feb 10. PMID: 33840437.
  17. Retzer A, Calvert M, Ahmed K, Keeley T, Armes J, Brown JM, Calman L, Gavin A, Glaser AW, Greenfield DM, Lanceley A, Taylor RM, Velikova G, Brundage M, Efficace F, Mercieca-Bebber R, King MT, Kyte D. International perspectives on suboptimal patient-reported outcome trial design and reporting in cancer clinical trials: A qualitative study. Cancer Med. 2021 Aug;10(16):5475-5487. doi: 10.1002/cam4.4111. Epub 2021 Jul 5. PMID: 34219395
  18. Snyder C, Gilbert A, Moher D, Kyte D, Daniels E, King M et al. Recommendations for including or reviewing patient-reported outcome endpoints in grant applications. BMJ. 2021 May 26.
  19. Withers H, Plumbley-Jones J, Pyatt E, Williams L, Yule L, Kyte D. The effectiveness of cognitive behavioural therapy versus antidepressants for treatment of post-stroke depression in adults. The British Student Doctor Journal. 2021;5(1):5–17. DOI: http://doi.org/10.18573/bsdj.169
  20. Calvert M, King M, Mercieca-bebber R, Aiyegbusi OL, Kyte D, Slade A et al. SPIRIT-PRO Extension explanation and elaboration: guidelines for inclusion of patient-reported outcomes in protocols of clinical trials. BMJ Open. 2021 Jan 8.
  21. Kyte D, Anderson N, Auti R, et al. Development of an electronic patient-reported outcome measure (ePROM) system to aid the management of patients with advanced chronic kidney disease. J Patient Rep Outcomes. 2020;4(1):55.
  22. Cruz Rivera S, McMullan C, Jones L, Kyte D, Slade A, Calvert M. The impact of patient-reported outcome data from clinical trials: perspectives from international stakeholders. J Patient Rep Outcomes. 2020;4(1):51.
  23. Aiyegbusi, O. L., Isa, F., Kyte, D., Pankhurst, T., Kerecuk, L., Ferguson, J., Lipkin, G.& Calvert, M Patient and clinician opinions of patient reported outcome measures (PROMs) in the management of patients with rare diseases: A qualitative study. (in press) Health Quality Life Outcomes.
  24. Care providers' and patients' attitudes toward using electronic-patient reported outcomes to support patients with traumatic brain injury: a qualitative study (PRiORiTy). McMullan C, Retzer A, Slade A, Kyte D, Jones L, Belli A, Calvert M, Turner GM. Brain Inj. 2020 May 11;34(6):723-731.
  25. Borregaard B, Pedersen SS, Berg SK, Dahl J, Ekholm O, Sibilitz K, Zwisler A, Lauck, SB, Kyte D, et al. What to expect after open heart valve surgery? Changes in health-related quality of life. Qual Life Res. 2019. Epub 2019/12/26.
  26. Rivera SC, Kyte DG, Aiyegbusi OL, Slade AL, McMullan C, Calvert MJ. The impact of patient-reported outcome (PRO) data from clinical trials: a systematic review and critical analysis. Health and quality of life outcomes. 2019;17(1):156. PubMed PMID: 31619266.
  27. Grove BE, Ivarsen P, de Thurah A, Schougaard LM, Kyte D, Hjollund NH. Remote follow-up using patient-reported outcome measures in patients with chronic kidney disease: the PROKID study - study protocol for a non-inferiority pragmatic randomised controlled trial. BMC Health Serv Res. 2019;19(1):631. PubMed PMID: 31484523.
  28. Bhachu HK, Cockwell P, Subramanian A, Nirantharakumar K, Kyte D, Calvert M. Cross-sectional observation study to investigate the impact of risk-based stratification on care pathways for patients with chronic kidney disease: protocol paper. BMJ Open. 2019 Jun 9;9(6):e027315. doi: 10.1136/bmjopen-2018-027315.
  29. Hjollund NHI, Valderas JM, Kyte D, Calvert MJ. Health Data Processes: A Framework for Analyzing and Discussing Efficient Use and Reuse of Health Data With a Focus on Patient-Reported Outcome Measures. J Med Internet Res. 2019 May 21;21(5):e12412.
  30. Anderson NE, Calvert M, Cockwell P, Dutton M, Kyte D. The Use of Patient-Reported Outcomes in Patients Treated With Maintenance Hemodialysis: A Perspective. Am J Kidney Dis. 2019 Apr 25. pii: S0272-6386(19)30167-2.
  31. Aiyegbusi OL, Kyte D, Cockwell P, Marshall T, Dutton M, Walmsley-Allen N, Slade A, McMullan C, Calvert M. Patient and Clinician Perspectives on Electronic Patient-Reported Outcome Measures in the Management of Advanced CKD: A Qualitative Study. Am J Kidney Dis. 2019 Apr 16. pii: S0272-6386(19)30613-4.
  32. Kyte D, Retzer A, Ahmed K, Keeley T, Armes J, Brown JM, Calman L, Gavin A, Glaser AW, Greenfield DM, Lanceley A, Taylor RM, Velikova G, Brundage M, Efficace F, Mercieca-Bebber R, King MT, Turner G, Calvert M. Systematic evaluation of Patient-Reported Outcome protocol content and reporting in cancer trials. J Natl Cancer Inst. 2019 Apr 11. pii: djz038.
  33. Williams FR, Vallance A, Faulkner T, Towey J, Durman S, Kyte D, Elsharkawy AM, Perera T, Holt A, Ferguson J, Lord JM, Armstrong MJ. Home-Based Exercise in Patients Awaiting Liver Transplantation: A Feasibility Study. Liver Transpl. 2019 Jul;25(7):995-1006.
  34. Miller C, Cross J, Power DM, Kyte D, Jerosch-Herold C. Development of a core outcome set for traumatic brachial plexus injuries (COMBINE): study protocol. BMJ Open. 2019;9(6):e030146.
  35. Turner G, Slade A, Retzer A, McMullan C, Kyte D, Belli A, Calvert M. Patient Reported Outcomes Research in Trauma: The PRiORiTy study qualitative protocol. BMJ Open. 2019 Jan 25;9(1):e024617. doi: 10.1136/bmjopen-2018-024617.
  36. Retzer A, Turner GM, Slade A, Kyte D, McMullan C, Jones L, Belli A, Calvert M. Electronic patient reported outcomes to support care of patients with traumatic brain injury: PRiORiTy study qualitative protocol. BMJ Open. 2019 Jan 25;9(1):e024617.
  37. Calvert M, Kyte D, Price G, Valderas JM, Hjollund NH. Maximising the impact of patient reported outcome assessment for patients and society. BMJ. 2019 Jan 24;364:k5267.
  38. Kaur G, Kyte D, Reeve BB, Basch E, Calvert M. Patient-reported outcome monitoring in a routine paediatric oncology setting: challenges and opportunities. Lancet Oncol. 2019 Jan;20(1):19-20. doi: 10.1016/S1470-2045(18)30785-X. PubMed PMID: 30614459.
  39. Turner GM, Slade A, Retzer A, McMullan C, Kyte D, Belli A, Calvert M. An introduction to patient-reported outcome measures (PROMs) in trauma. J Trauma Acute Care Surg. 2019 Feb;86(2):314-320. doi: 10.1097/TA.0000000000002102. PubMed PMID: 30376536.
  40. Kyte D, Bishop J, Brettell E, Calvert M, Cockwell P, Dutton M, Eddington H, Hadley G, Ives NJ, Jackson LJ, Stringer S, Valente M. Use of an electronic patient-reported outcome measure in the management of patients with advanced chronic kidney disease: the RePROM pilot trial protocol. BMJ Open. 2018 Oct 28;8(10):e026080.
  41. Anderson NE, Calvert M, Cockwell P, Dutton M, Aiyegbusi OL, Kyte D. Using patient-reported outcome measures (PROMs) to promote quality of care in the management of patients with established kidney disease requiring treatment with haemodialysis in the UK (PROM-HD): a qualitative study protocol. BMJ Open. 2018 Oct 28;8(10):e021532.
  42. Aiyegbusi OL, Kyte D, Cockwell P, Marshall T, Dutton M, Walmsley-Allen N, Auti R, Calvert M. Development and usability testing of an electronic patient-reported outcome measure (ePROM) system for patients with advanced chronic kidney disease. Comput Biol Med. 2018 Oct 1;101:120-127.
  43. Isa F, Turner GM, Kaur G, Kyte D, Slade A, Pankhurst T, Kerecuk L, Keeley T, Ferguson J, Calvert M. Patient-reported outcome measures used in patients with primary sclerosing cholangitis: a systematic review. Health Qual Life Outcomes. 2018 Jul 5;16(1):133.
  44. Retzer A, Kyte D, Stephens R, Glaser A, Calman L, Calvert M. The importance of patient-reported outcomes in cancer studies. Expert Review of Quality of Life in Cancer Care, 3:2-3, 65-71.
  45. Mercieca-Bebber R, Calvert M, Kyte D, Stockler M, King MT. The administration of patient-reported outcome questionnaires in cancer trials: Interviews with trial coordinators regarding their roles, experiences, challenges and training. Contemp Clin Trials Commun. 2017 Nov 23;9:23-32.
  46. Slade A, Isa F, Kyte D, Pankhurst T, Kerecuk L, Ferguson J, Lipkin G, Calvert M. Patient reported outcome measures in rare diseases: a narrative review. Orphanet J Rare Dis. 2018 Apr 23;13(1):61.
  47. Retzer A, Keeley T, Ahmed K, Armes J, Brown JM, Calman L, Copland C, Efficace F, Gavin A, Glaser A, Greenfield DM, Lanceley A, Taylor RM, Velikova G, Brundage M, Mercieca-Bebber R, King MT, Calvert M, Kyte D. Evaluation of patient-reported outcome protocol content and reporting in UK cancer clinical trials: the EPiC study qualitative protocol. BMJ Open. 2018 Feb 3;8(2):e017282.
  48. Calvert M, Kyte D, Mercieca-Bebber R, Slade A, Chan AW, King MT; the SPIRIT-PRO Group, Hunn A, Bottomley A, Regnault A, Chan AW, Ells C, O'Connor D, Revicki D, Patrick D, Altman D, Basch E, Velikova G, Price G, Draper H, Blazeby J, Scott J, Coast J, Norquist J, Brown J, Haywood K, Johnson LL, Campbell L, Frank L, von Hildebrand M, Brundage M, Palmer M, Kluetz P, Stephens R, Golub RM, Mitchell S, Groves T. Guidelines for Inclusion of Patient-Reported Outcomes in Clinical Trial Protocols: The SPIRIT-PRO Extension. JAMA. 2018 Feb 6;319(5):483-494.
  49. Chauhan A, de Wildt G, Virmond MDCL, Kyte D, Galan NGA, Prado RBR, Shyam-Sundar V. Perceptions and experiences regarding the impact of race on the quality of healthcare in Southeast Brazil: a qualitative study. Ethn Health. 2018 Jan 24:1-17.
  50. Williams FR, Vallance A, Faulkner T, Towey J, Kyte D, Durman S, Johnson J, Holt A, Perera MT, Ferguson J, Armstrong MJ. Home-based exercise therapy in patients awaiting liver transplantation: protocol for an observational feasibility trial. BMJ Open. 2018 Jan 21;8(1):e019298.
  51. Aiyegbusi OL, Kyte D, Cockwell P, Anderson N, Calvert M. A patient-centred approach to measuring quality in kidney care: patient-reported outcome measures and patient-reported experience measures. Curr Opin Nephrol Hypertens. 2017 Nov;26(6):442-449.
  52. Cruz Rivera S, Kyte DG, Aiyegbusi OL, Keeley TJ, Calvert MJ. Assessing the impact of healthcare research: A systematic review of methodological frameworks. PLoS Med. 2017 Aug 9;14(8):e1002370.
  53. Aiyegbusi OL, Kyte D, Cockwell P, Marshall T, Dutton M, Slade A, Marklew N, Price G, Verdi R, Waters J, Sharpe K, Calvert M. Using Patient-Reported Outcome Measures (PROMs) to promote quality of care and safety in the management of patients with Advanced Chronic Kidney disease (PRO-trACK project): a mixed-methods project protocol. BMJ Open. 2017 Jun 30;7(6):e016687.
  54. Aiyegbusi OL, Kyte D, Cockwell P, Marshall T, Gheorghe A, Keeley T, Slade A, Calvert M. Measurement properties of patient-reported outcome measures (PROMs) used in adult patients with chronic kidney disease: A systematic review. PLoS One. 2017 Jun 21;12(6):e0179733.
  55. Dean S, Mathers JM, Calvert M, Kyte DG, Conroy D, Folkard A, Southworth S, Murray PI, Denniston AK. "The patient is speaking": discovering the patient voice in ophthalmology. Br J Ophthalmol. 2017 Jun;101(6):700-708.
  56. Mercieca-Bebber R, Friedlander M, Calvert M, Stockler M, Kyte D, Kok PS, King MT. A systematic evaluation of compliance and reporting of patient-reported outcome endpoints in ovarian cancer randomised controlled trials: implications for generalisability and clinical practice. J Patient Rep Outcomes. 2017;1(1):5.
  57. Kyte D, Cockwell P, Lencioni M, Skrybant M, Hildebrand MV, Price G, Squire K, Webb S, Brookes O, Fanning H, Jones T, Calvert M. Reflections on the national patient-reported outcome measures (PROMs) programme: Where do we go from here? J R Soc Med. 2016 Dec;109(12):441-445. PubMed PMID: 27923896.
  58. Jesky MD, Dutton M, Dasgupta I, Yadav P, Ng KP, Fenton A, Kyte D, Ferro CJ, Calvert M, Cockwell P, Stringer SJ. Health-Related Quality of Life Impacts Mortality but Not Progression to End-Stage Renal Disease in Pre-Dialysis Chronic Kidney Disease: A Prospective Observational Study. PLoS One. 2016 Nov 10;11(11):e0165675.
  59. Aiyegbusi OL, Kyte D, Cockwell P, Marshall T, Keeley T, Gheorghe A, Calvert M. Measurement properties of patient-reported outcome measures (PROMs) used in adult patients with chronic kidney disease: a systematic review protocol. BMJ Open. 2016 Oct 12;6(10):e012014.
  60. Kyte D, Ives J, Draper H, Calvert M. Current practices in patient-reported outcome (PRO) data collection in clinical trials: a cross-sectional survey of UK trial staff and management. BMJ Open. 2016 Oct 3;6(10):e012281.
  61. Ahmed K, Kyte D, Keeley T, Efficace F, Armes J, Brown JM, Calman L, Copland C, Gavin A, Glaser A, Greenfield DM, Lanceley A, Taylor R, Velikova G, Brundage M, Mercieca-Bebber R, King MT, Calvert M. Systematic evaluation of patient-reported outcome (PRO) protocol content and reporting in UK cancer clinical trials: the EPiC study protocol. BMJ Open. 2016 Sep 21;6(9):e012863.
  62. Mercieca-Bebber R, Friedlander M, Kok PS, Calvert M, Kyte D, Stockler M, King MT. The patient-reported outcome content of international ovarian cancer randomised controlled trial protocols. Qual Life Res. 2016 Oct;25(10):2457-2465.
  63. Kyte D, Ives J, Draper H, Calvert M. Management of Patient-Reported Outcome (PRO) Alerts in Clinical Trials: A Cross Sectional Survey. PLoS One. 2016 Jan 19;11(1):e0144658.
  64. Kyte D, Reeve BB, Efficace F, Haywood K, Mercieca-Bebber R, King MT, Norquist JM, Lenderking WR, Snyder C, Ring L, Velikova G, Calvert M. International Society for Quality of Life Research commentary on the draft European Medicines Agency reflection paper on the use of patient-reported outcome (PRO) measures in oncology studies. Qual Life Res. 2016 Feb;25(2):359-362.
  65. Calvert M, Thwaites R, Kyte D, Devlin N. Putting patient-reported outcomes on the 'Big Data Road Map'. J R Soc Med. 2015 Aug;108(8):299-303.
  66. Calvert M, Kyte D, von Hildebrand M, King M, Moher D. Putting patients at the heart of health-care research. Lancet. 2015 Mar 21;385(9973):1073-4.
  67. Kyte DG, Calvert M, van der Wees PJ, ten Hove R, Tolan S, Hill JC. An introduction to patient-reported outcome measures (PROMs) in physiotherapy. Physiotherapy. 2015 Jun;101(2):119-25.
  68. Calvert M, Kyte D, Duffy H, Gheorghe A, Mercieca-Bebber R, Ives J, Draper H, Brundage M, Blazeby J, King M. Patient-reported outcome (PRO) assessment in clinical trials: a systematic review of guidance for trial protocol writers. PLoS One. 2014 Oct 15;9(10):e110216.
  69. Kyte D, Duffy H, Fletcher B, Gheorghe A, Mercieca-Bebber R, King M, Draper H, Ives J, Brundage M, Blazeby J, Calvert M. Systematic evaluation of the patient-reported outcome (PRO) content of clinical trial protocols. PLoS One. 2014 Oct 15;9(10):e110229.
  70. Green A, Liles C, Rushton A, Kyte DG. Measurement properties of patient-reported outcome measures (PROMS) in Patellofemoral Pain Syndrome: a systematic review. Man Ther. 2014 Dec;19(6):517-26.
  71. Freemantle N, Shallcross LJ, Kyte D, Rader T, Calvert MJ. Oseltamivir: the real world data. BMJ. 2014 Apr 9;348:g2371. doi: 10.1136/bmj.g2371. Review. PubMed PMID: 24811409.
  72. Denniston AK, Kyte D, Calvert M, Burr JM. An introduction to patient-reported outcome measures in ophthalmic research. Eye (Lond). 2014 Jun;28(6):637-45.
  73. Gheorghe A, Kyte D, Calvert M. The need for increased harmonisation of clinical trials and economic evaluations. Expert Rev Pharmacoecon Outcomes Res. 2014 Apr;14(2):171-3.
  74. Kyte D, Ives J, Draper H, Keeley T, Calvert M. Inconsistencies in quality of life data collection in clinical trials: a potential source of bias? Interviews with research nurses and trialists. PLoS One. 2013 Oct 4;8(10):e76625.
  75. Kyte D, Draper H, Calvert M. Patient-reported outcome alerts: ethical and logistical considerations in clinical trials. JAMA. 2013 Sep 25;310(12):1229-30.
  76. Kyte D, Rushton A, Eveleigh G. Factors affecting myofascial pain pattern recognition in musculoskeletal therapists: an exploratory study. International Journal of Therapy & Rehabilitation. 2012 Mar 1;19(3).

Conferences

Date

Conference

Contribution (if appropriate)

 2023

UK PROMs Conference, Sheffield, UK

Oral presentation. Derek Kyte, Benjamin R. Fletcher, Mike Horton, Sarah Damery, Olalekan Lee Aiyegbusi, Nicola Anderson, Andrew Bissell, Melanie Calvert, Paul Cockwell, James Ferguson, Muirne C.S. Paap, Chris Sidey-Gibbons, Neil Turner, Rav Verdi, Anita Slade.

Development and validation of the kidney symptom burden questionnaire (KSB-Q): Rasch Analysis.

2022

UK Kidney Week (Virtual)

Oral presentation. N Anderson, D Kyte, C McMullan, O Aiyegbusi, P Cockwell, M Calvert Using electronic Patient-Reported Outcome Measures (ePROs) to promote quality of care and safety in the management of patients with End Stage Kidney Disease: A Review of Electronic Patient-Reported Outcomes Systems used in Nephrology settings – a mixed methods study

2021

International Society for Quality of Life Research Annual Conference (virtual)

Invited Symposium. PROMs in Telehealth. ISOQOL 28th Annual Conference, 2021.

 

2020

UK Kidney Week (Virtual)

Oral presentation. N Anderson, D Kyte, C McMullan, O Aiyegbusi, P Cockwell, M Calvert Using electronic Patient-Reported Outcome Measures (ePROs) to promote quality of care and safety in the management of patients with End Stage Kidney Disease: a qualitative study

2020

International Society for Quality of Life Research Annual Conference (Virtual)

Oral presentation. N Anderson, D Kyte, C McMullan, O Aiyegbusi, P Cockwell, M Calvert Using electronic Patient-Reported Outcome Measures (ePROs) to promote quality of care and safety in the management of patients with End Stage Kidney Disease: a qualitative study

2019

NCRI Living With & Beyond Cancer Workshop, Manchester, UK

Keynote. Systematic Evaluation of Patient-Reported Outcome Protocol Content and Reporting in Cancer Trials. NCRI Living With & Beyond Cancer Workshop, Manchester, 2019.

2019

UK Kidney Week, Brighton

Invited speaker: Symptom monitoring in advanced chronic kidney disease using electronic patient-reported outcomes. UK Kidney Week, Brighton, UK, June, 2019

2018

National Institute for Health and Care excellence, London

Invited speaker. National Institute for Health and Care Excellence, London, October 2018

2018

International Society for Quality of Life Research Annual Conference, Dublin

Symposium. Minimising Research Waste and Maximising the Impact of Patient Reported Outcome Trial Results. ISOQOL 25TH Annual Conference, Dublin, 2018.

2018

UK PROMs Conference, University of Birmingham

Oral presentation. A survey of Patient Reported Outcome Measures (PROMs) used in General Practice in England. G Turner, S Finnikin, T Keeley, D Kyte, C Taylor, H Stokes-Lampard, M Calvert, UK PROMs Conference, University of Birmingham, 2018.

2018

UK PROMs Conference, University of Birmingham

Oral presentation. Assessing the impact of patient-reported outcome (PRO) data from clinical trials: a systematic review. S Cruz, D Kyte, A Slade, O Aiyegbusi, L Jones, C McMullan, UK PROMs Conference, University of Birmingham, 2018.

2018

UK PROMs Conference, University of Birmingham

Oral presentation. Embedding patient and public involvement within the Centre for Patient Reported Outcomes Research. G Turner, O Aiyegbusi, D Kyte, A Slade, M Skrybant, G Price, M Calvert, UK PROMs Conference, University of Birmingham, 2018.

2018

UK PROMs Conference, University of Birmingham

Oral presentation. The use of an electronic Patient-Reported Outcome Measure in the management of patients with Advanced Chronic Kidney Disease: the RePROM Pilot Trial, UK PROMs Conference, University of Birmingham, 2018.

2018

UK PROMs Conference, University of Birmingham

Oral presentation. Increasing capture of patient-reported outcomes in trauma research. G Turner, A Retzer, A Slade, D Kyte, K Piper, T Belli, M Calvert, UK PROMs Conference, University of Birmingham, 2018.

2018

UK PROMs Conference, University of Birmingham

Oral presentation. A qualitative study of patients’ and clinicians’ perspectives on the use of electronic Patient-Reported Outcome measures (ePROMs) in the management of patients with Advanced Chronic Kidney Disease (PRO-trACK Project). O Aiyegbusi, D Kyte, P Cockwell, T Marshall, M Dutton, N Walmsley-Allen, R Auti, M Calvert, UK PROMs Conference, University of Birmingham, 2018.

2017

UK PROMs Conference, University of Oxford

Oral presentation. Anderson N, Dutton M, Cockwell P, Calvert M, Kyte D. The PRO-HD study: Using Patient Reported Outcome measures (PROs) to promote quality of care and safety in the management of patients with end stage renal disease requiring treatment with haemodialysis. UK PROMs Conference, University of Oxford, 2017.

2017

UK Kidney Week, Liverpool

Oral presentation. Anderson N, Dutton M, Cockwell P, Calvert M, Kyte D. The PRO-HD study: Using Patient Reported Outcome measures (PROs) to promote quality of care and safety in the management of patients with end stage renal disease requiring treatment with haemodialysis. UK Kidney Week, Liverpool, 2017.

2017

International Society for Quality of Life Research Annual Conference, Philadelphia

Conference workshop. Improving the design of clinical trials with patient-reported outcomes: guidance for protocol writers. ISOQOL 24th Annual Conference, Philadelphia, 2017.

2017

International Society for Quality of Life Research Annual Conference, Philadelphia

Oral presentation. Anderson N, Dutton M, Cockwell P, Calvert M, Kyte D. The PRO-HD study: Using Patient Reported Outcome measures (PROs) to promote quality of care and safety in the management of patients with end stage renal disease requiring treatment with haemodialysis. ISOQOL 24TH Annual Conference, Philadelphia, USA, 2017.

2017

International Society for Quality of Life Research Annual Conference, Philadelphia

Oral presentation. The use of electronic Patient-Reported Outcomes (ePROs) in the management of patients with advanced chronic kidney disease – A pilot/feasibility study for a randomised controlled trial. ISOQOL 24th Annual Conference, Philadelphia, 2017.

2017

International Society for Quality of Life Research Annual Conference, Philadelphia

Oral presentation. Systematic evaluation of patient-reported outcome (PRO) protocol content and reporting in UK cancer clinical trials: the EPiC study. ISOQOL 24th Annual Conference, Philadelphia, 2017.

2017

National Cancer Research Institute (NCRI) Cancer Conference, Liverpool

Oral presentation. Systematic evaluation of patient-reported outcome (PRO) protocol content and reporting in UK cancer clinical trials: the EPiC study. National Cancer Research Institute (NCRI) Cancer Conference, Liverpool, November, 2017.

2016

NIHR School for Primary Care Research Ten-year Anniversary Showcase, London

Poster presentation. Inconsistencies in Patient-Reported Outcome (PRO) Data Collection in Clinical Trials: A Potential Source of Bias? NIHR School for Primary Care Research Ten-year Anniversary Showcase, Wellcome Trust, London, 2016.

2016

UK National PROMs Conference, Sheffield

Oral presentation. Current Practices in Patient-Reported Outcome (PRO) Data Collection in Trials: A Survey of UK trial staff and management, UK National PROMs Conference, Sheffield, UK, 2016

2016

International Society for Quality of Life Research Annual Conference, Copenhagen

Oral presentation. Aiyegbusi O, Kyte D, Cockwell P, Marshall T, Gheorghe A, Keeley T, Slade A, Calvert M. Measurement properties of patient-reported outcome measures (PROMs) used in adult patients with chronic kidney disease: a systematic review. ISOQOL Conference, Copenhagen, 2016.

2016

International Society for Quality of Life Research Annual Conference, Copenhagen

Oral presentation. Isa F, Turner G, Kyte D, Slade A, Pankhurst T, Kerecuk L, Keeley T, Ferguson J, Calvert M Patient reported outcome measures used in patients with primary sclerosing cholangistis: systematic review. ISOQOL Conference, Copenhagen, 2016.

2015

International Society for Quality of Life Research Annual Conference, Vancouver

Conference workshop. Improving the design of clinical trials with patient-reported outcomes: guidance for protocol writers. ISOQOL Annual Conference, Vancouver, 2015.

2015

International Society for Quality of Life Research Annual Conference, Vancouver

Oral presentation. Management of Patient-Reported Outcome Alerts: A Cross Sectional Survey, ISOQOL Annual Conference, Vancouver, BC, Canada, 2015.

2014

North American Primary Care Research Group (NAPCRG) Annual Meeting, New York

Oral presentation. Evaluation of the patient-reported outcome (PRO) content of clinical trial protocols. North American Primary Care Research Group (NAPCRG) Annual Meeting, New York 2014.

2014

International Society for Quality of Life Research, Berlin

Oral presentation. Evaluation of the patient-reported outcome (PRO) content of clinical trial protocols. International Society for Quality of Life Research (ISOQOL) 21st Annual Conference in Berlin, Germany, 2014.

2013

MRC Clinical Trial Methodology Conference, Edinburgh

Oral presentation. Inconsistencies in quality of life data collection in clinical trials: a potential source of bias? Interviews with research nurses and trialists. 2nd MRC Clinical Trial Methodology Conference, Edinburgh 2013.

2013

International Society for Quality of Life Research, Miami

Oral presentation. Inconsistencies in quality of life data collection in clinical trials: a potential source of bias? Interviews with research nurses and trialists. International Society for Quality of Life Research, 20th annual conference, Miami 2013.

2013

International Society for Quality of Life Research, Miami

Invited symposium. Calvert M, Kyte D, Duffy H, Gheorghe A, Draper H, Ives J, Brundage M, Blazeby J, Mercieca-Bebber R, King M. PRO trial protocols: the current state of play. International Society for Quality of Life Research, 20th annual conference, Miami 2013.

2012

International Society for Quality of Life Research, Budapest

Is ‘In-Trial’ Quality of Life Guidance Lacking? A Systematic Review Employing Qualitative Content Analysis. International Society for Quality of Life Research, 19th annual conference, Budapest, 2012.

2011

World Confederation of Physical Therapy Conference, Amsterdam

Myofascial pain referral: pattern identification in cervical dysfunction. World Confederation of Physical Therapy Conference, Amsterdam 2011.

External Roles

Research grants and awards received

Total grant income >£3 million.

  1. A pilot study to assess the safety, effectiveness and, practical utility of remote patient monitoring to guide the timing of valve intervention in patients with asymptomatic severe aortic stenosis (APRAISE-AS). NIHR RfPB Competition 43 Stage 2 - West Midlands 2021, £249,540.00. Co-I.
  2. Development of a disease-specific item bank and multidimensional computerized adaptive test (MCAT) to measure health-related quality of life and symptom burden in patients with chronic kidney disease. Kidney Research UK £176,622.07. PI.
  3. Calvert M, Kyte D, Price G. PROmics – value proposition, route to market and business model, Enterprising Birmingham Fund Award, £9,960. Feb 19-Apr 19. Co-I.
  4. Kaur G, Calvert M, Kyte D, Kearns P. Conduct qualitative interviews to inform study design and methods for fellowship proposal. Wellcome Trust ISSF: Digital Health Pilot Grant, £4,454. Feb 19-Jun 19. Co-I.
  5. Anderson N, Kyte D, Dutton M, Cockwell P, Calvert M. (2019-22) Using electronic Patient-Reported Outcome Measures (ePROMs) to promote quality of care and safety in the management of patients with End Stage Kidney Disease requiring treatment with Haemodialysis (HD) in research and routine clinical settings: a mixed-methods study. NIHR CDRF. £258,821.06. Co-I.
  6. Newsome P, Calvert M, Kyte D, Price P, Harding R, Dunster H, Gostick N, Dignio Ltd. Patient-reported outcomes assessment to support accelerated access to advanced cell and gene therapies: PROmics. Innovate UK, £1,189,402 Dec 18-Mar 21. Co-I.
  7. Calvert M, Kyte D, Price G, Dunster H, Gostick N, Harding R, Ball S, Dahle L, Garner K. PROmics Accelerated access to new medicines – promoting patient safety and quality of life. Medical Research Council (MRC) Proximity to Discovery (PtD), £9,946, Sep 18-Feb 19. Co-I.
  8. NIHR Biomedical Research Centre (BRC) - Core Theme. £109,802.00. Co-I.
  9. Kyte D. Feasibility Study for a Randomised Controlled Trial of electronic Patient-Reported Outcome Measure (ePROM) Use in the Management of Patients with Advanced Chronic Kidney Disease (e-PROM CKD) £537,221 NIHR PDF Jan2017-Dec2020. PI
  10. Kyte D, Cockwell P, Dutton M, Calvert M The use of an electronic Patient-Reported Outcome Measure (ePROM) in the Management of Dialysis Patients £41000 Kidney Patients Association Oct 2016-Oct 2018, PI
  11. Kyte D, Calvert M, Copland C, Armes P, Taylor R, Glaser A, Gavin A, Greenfield D, Brown J, Velikova G. Evaluation of Patient-Reported Outcome (PRO) Protocol Content and Reporting in UK Cancer Clinical Trials – EPiC £199,838.90 Macmillan Cancer Support March 2016-Aug 2018, PI
  12. Calvert M, Kyte D, Draper H, Ives J, Brundage M, CoastJ, Draper H, von Hildebrand M, Ives J, Price G, Roberts L, King M, Mercieca-Bebber R, Blazeby J, Altman D, Brown J, Slade A. Development of the SPIRIT-PRO Extension £55,000 Macmillan Cancer Support Jan2017-December 2017, Co-I
  13. Calvert M, Kyte D, Ahmed K, Retzer A, Slade A. Increased participation of Black and Minority Ethnic (BME) Groups in primary care clinical trials involving patient-reported outcomes (PROs). £22,500 West Midlands CRN 2016-17, Co-I
  14. Keeley T, Kyte, D, Turner G, Taylor C, Stokes-Lampard H, Calvert M. Exploring the use of PROs in Primary Care £10,001 Wellcome Trust Institutional Strategic Support Fund May 2016-Sept 2016, Co-I
  15. Gibbons C, Stillwell D, Kyte D, Calvert M, Williams J, Pirzemek L, Cockwel P, Ball S, Ferguson J. Evaluating the implementation of novel computational strategies for the accurate and efficient collection and feedback of patient-reported data in an NHS patient portal. £13,000 ESRC Impact Acceleration Account (IAA) Programme 2016-17, Co-I
  16. Calvert M, Kyte D, Keeley T, Ahmed K. PROLearn £45,000 NIHR CRN Nov 2015-Nov2016, Co-I
  17. Calvert M, Kyte D, Keeley T, Ferguson J, Pankhurst T, Kerecuk L. Selection of Patient Reported Outcomes for Rare Disease Metchley Park Medical Society £45,388 Dec 2015-Dec 2016, Co-I
  18. Cruz S, Kyte D, Keeley T, Calvert M. Mexican National Council for Science and Technology Impact of PRO trial data on health policy and clinical practice £88,000 Oct 2015-Oct 2019, Co-I and second supervisor, Co-I
  19. Calvert M, Parry J, Greenfield S, Kyte D, Marshall T, Cockwell P, Gayle N, Litchfield I Health Foundation £280,000, Oct 2015-Oct 2019, Co-I
  20. Ives J, Draper H, Calvert M, Kyte D. What do potential research participants understand about patient reported outcome measurement and management? An investigation of trial information provision. £29,051 MRC Midland Hub for Trials Methodology Research 2014-2015, Co-I
  21. Calvert M, Kyte D, Draper H, Ives J, Gheorghe A, Brundage M, King M, Mercieca-Bebber R, Blazeby J. Evaluation of patient reported outcomes in clinical trials: systematic review of trial protocols NIHR National School Primary Care Research, £23,976 2013-2014, Co-I
  22. Kyte D, Calvert M, Draper H, Ives J Methodological and ethical issues in health-related quality of life research NIHR National School Primary Care Research, £85,260 2011-2014, PI
  23. Calvert M, Kyte D. (2012) Best-Practice for Patient Reported Outcomes (PROs) in Randomised Clinical Trials. £7000 Institute of Advanced Studies, University of Birmingham, Co-PI
  24. Kyte D. Masters in Clinical Practice Sponsorship Scheme. £6800 Birmingham and the Black Country Strategic Health Authority 2004-2009, PI