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Dr Steven J Coles

Senior Lecturer in Biochemistry

Institute of Science & the Environment

Contact Details

email: s.coles@worc.ac.uk

tel: 01905 542577

Steve achieved a first class honours degree in Biochemistry and Molecular Biology at the University of the West of England (UWE, 2005) before undertaking a PhD in Biomedical Sciences (Neurochemistry) which he attained in 2008 (UWE).

Following his studies, Steve joined the School of Medicine at Cardiff University as a post-doctoral research scientist (Department of Haematology), where his research focussed on tumour immunology and immunotherapy in a type of blood cancer known as acute myeloid leukaemia (AML).

Steve joined us in February 2013 and is our award leader for the BSc Biochemistry programme. Since joining us, Steve has introduced several new modules to the bioscience degree programmes which are informed by his research and expertise, including: BIOS2110 Immunology and BIOS3113 Biochemistry of Cancer. Steve is committed to teaching and learning and has achieved several student led teaching awards in recognition of his efforts which include: Outstanding Academic Tutor (2014), Best Module (with Dr Mike Wheeler) for BIOS1212 Introduction to Biological Chemistry and Genetics (2014), Best Module (with Dr Mike Wheeler) for BIOS2201 Molecular and Cellular Biology (2015) and Outstanding University Teacher (2015).

Undergraduate teaching

Undergraduate teaching

Module Leader

First Year
BIOS1205 Introduction to Biological Chemistry (15 credit)
BIOS1212 Introduction to Biological Chemistry & Genetics (30 credit)
BIOS1210 Comparative Animal Physiology (15 credit)

Second Year
BIOS2110 Immunology (15 credit)

Third Year
BIOS3113 Biochemistry of Cancer (15 credit)
BIOS3116 Clinical Chemistry (15 credit)

Steve also contributes to teaching on several other modules including: BIOS1201 Cell Biology, BIOS1211 Introduction to Human Health & Disease, BIOS2200 Project & Career Development, BIOS2201 Molecular & Cellular Biology (semester 2) and BIOS2023 Microbiology.

Research

Research

Steve is a founding member of the Worcester Biomedical Research Group (WBRG) and currently leads several research projects:

Post-doctoral
Dr Alex Wadley (PhD) - ‘Validating a Novel Flow Cytometric Assay to Assess the Functional Consequence of Intracellular Thiol-Redox Status in Viable Peripheral Blood Mononuclear Cells: implications for AML anti-tumour immunity’­ (as Principle Investigator) 2014 – 2017.

PhD Students
Mr James Hillier (BSc, MSc) - The Role of BCAT1 in the Development and Treatment of AML’ (as Director of Studies) 2015 – 2018.

Sr Angela Doughty(BSc) - Monitoring Intracellular and Extracellular Markers of Oxidative Stress in Acute Coronary Syndrome’ (as Director of Studies) 2015 – 2020 part-time.

Funding and Awards

2015 - £28,900 (CAPES: Ministry of Education, Brazil) ‘The role of GLUT12 transporters in disease pathogenesis’ as Co-Investigator with Dr Allain Bueno (Principle Investigator)
2015 - £9,756 (Sir Halley Stewart Trust) ‘High throughput in vitro screening of novel therapeutics for the treatment of parasitic infection and leukaemia (AML)’ as Co-Investigator with Dr Wayne Heaselgrave (University of Wolverhampton)
2015 - £44,589 (University of Worcester) PhD Studentship ‘The role of BCAT1 in the development and treatment of AML’
2014 - £91,328 (University of Worcester) Post-Doctoral Research Associate ‘Validating a Novel Flow Cytometric Assay to Assess the Functional Consequence of Intracellular Thiol-Redox Status in Viable Peripheral Blood Mononuclear Cells: implications for AML anti-tumour immunity’
2014 - £1,000 (University of Worcester) Summer Studentship ‘cloning BCAT1 into a lentiviral vector’
2013 - £1,000 (University of Worcester) Summer Studentship ‘Detecting intracellular protein targets of oxidative stress’
2013 - £1,000 (University of Worcester) Summer Studentship ‘Plasma markers of oxidative stress’
2012 - £300 (BioLegend) ‘Young investigator award’
2011 - £200 (William Morgan Trust) ‘Travel award to BSI congress’
2011 - £500 (British Society for Immunology) ‘Travel award to BSI congress’
2010 - £500 (American Society for Hematology) ‘Travel award to ASH annual meeting’
2010 - £1,000 (British Society of Haematology) ‘Travel award to ASH annual meeting’

Collaborators

Dr Wayne Heaselgrave (PhD) - University of Wolverhampton
Prof Myra Conway (PhD) - University of the West of England
Prof Richard Darley (PhD) - Cardiff University
Dr Paul Hole (PhD) - Cardiff University
Dr Rhys Morgan (PhD) - University of Bristol
Dr Fiona Clark (MB, ChB, FRCP, FRCPath) - Worcester Acute Hospitals NHS Trust and University of Birmingham

Publications

Publications

Journal articles

Coles, S.J., Gilmour, M., Reid, R., Knapper, S., Man, S., Tonks, A. and Darley R.L. (2015) The immunosuppressive ligands PD-L1 and CD200 are linked in AML immunosuppression: identification of a new immunotherapeutic synapse. Leukemia DOI: 10.1038/leu.2015.62.
http://www.ncbi.nlm.nih.gov/pubmed/25748687

Agathanggelou, A., Weston, V.J., Perry, T., Davies, N.J., Skowronska, A., Payne, D.T., Fossey, J.S., Oldreive, C.E., Wei, W., Pratt, G., Parry, H., Oscier, D., Coles, S.J., Hole, P.S., Darley, R.L., McMahon, M., Hayes, J.D., Moss, P., Stewart, G., Taylor, M.R. and Stankovic, T. (2015) Targeting the ATM-null phenotype in chronic lymphocytic leukemia with pro-oxidants. Haematologica DOI: 10.3324/haematol.2014.115170.
http://www.ncbi.nlm.nih.gov/pubmed/25840602

Coles, S.J., Hills, R.K., Wang, E., Man, S., Burnett, A.K., Darley, R.L. and Tonks, A. (2012) Increased CD200 expression in acute myeloid leukemia is linked with an increased frequency of FoxP3+ regulatory T-cells. Leukemia 26(9), 2146-2148.**
http://www.ncbi.nlm.nih.gov/pubmed/22430636

Coles, S.J., Hills, R.K., Wang, E., Man, S., Burnett, A.K., Darley, R.L. and Tonks, A. (2012) Expression of CD200 on AML blasts directly suppresses memory T-cell function. Leukemia 26(9), 2148-2151.**
http://www.ncbi.nlm.nih.gov/pubmed/22430635
**back to back publications

Coles, S.J., Hancock, J.T. and Conway M.E. (2012) Differential redox potentials between the human cytosolic and mitochondrial branched chain aminotransferase. ABBS 44(2), 172-176.
http://www.ncbi.nlm.nih.gov/pubmed/22107788

§Coles, S.J., Wang E.C., Man S., Hills, R.K., Burnett A.K., Tonks A. and Darley R.L. (2011) CD200 expression suppresses natural killer cell function and directly inhibits patients anti-tumour response in acute myeloid leukemia.  Leukemia 25(5), 792-799.
http://www.ncbi.nlm.nih.gov/pubmed/21274000
§Article has received Faculty of 1000 recommendation: http://f1000.com/8349957#recommendations

Walsby, E.J., Coles, S.J., Knapper, S. and Burnett, A.K. (2011) Topoisomerase II inhibitor voreloxin causes cell cycle arrest and apoptosis in myeloid leukaemia cells and acts in synergy with cytarabine. Haematologica 96(3), 393-399.
http://www.ncbi.nlm.nih.gov/pubmed/21134979

Coles, S.J., Easton P., Sharrod H., Hutson, S.M., Hancock, J.T. and Conway, M.E. (2009) S-nitrosoglutathione inactivation of the mitochondrial and cytosolic BCAT proteins: S-nitosylation and S-thiolation.  Biochemistry 48(3), 645-656.
http://www.ncbi.nlm.nih.gov/pubmed/19119849

Hutson, S.M., Poole, L.B., Coles, S.J. and Conway, M.E. (2008) Redox Regulation and Trapping Sulphenic Acid in the Peroxide Sensitive Human Mitochondrial Branched Chain Aminotransferase.  Methods Mol Bol 476, 139-152.
http://www.ncbi.nlm.nih.gov/pubmed/19157014

*Conway, M.E., *Coles, S.J., Islam, M.M. and Hutson, S.M. (2008) Regulatory control of human cytosolic branched-chain aminotransferase by oxidation and S-glutathionylation and its interaction with redox sensitive neuronal proteins.  Biochemistry 47(19), 5465-5479. *Contributed equally to this study.
http://www.ncbi.nlm.nih.gov/pubmed/18419134

 

Conference Papers and Published Abstracts$

Coles, S.J., Gilmour, M., Reid, R., Knapper, S., Man, S., Tonks, A. and Darley R.L. (2014) CD200 and PD-L1 in AML are associated with expanded late differentiated CD8+ T cells and a decreased CD4:CD8 ration; a new link between distinct immunosuppressive pathways. Blood (ASH Annual Meeting Abstracts) 124, 992. Poster$ (clinically relevant)
http://www.bloodjournal.org/content/124/21/992?sso-checked=true

Coles, S.J., Hills, R.K., Wang, E., Man, S., Burnett, A.K., Darley, R.L. and Tonks, A. (2011). CD200 inhibits memory Th1 cell function in acute myeloid leukaemia. Immunology (BSI Annual Meeting Abstracts) 135, 178. Poster$
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2567.2011.03534.x/abstract

Coles, S.J., Man, S., Hills, R.K., Wang, E., Burnett, A.K., Darley, R.L. and Tonks, A. (2010). Over-expression of CD200 in Acute Myeloid Leukemia Mediates the Expansion of Regulatory T-lymphocytes and Directly Inhibits Natural Killer Cell Tumor Immunity. Blood (ASH Annual Meeting Abstracts) 116, 491. Oral$ (clinically relevant)
http://abstracts.hematologylibrary.org/cgi/content/abstract/116/21/491

Coles, S.J., Man, S., Wang, E., Burnett, A.K., Darley, R.L. and Tonks, A. (2010). RUNX1-ETO target genes; the role of CD200 mediated tumour immunity in AML. 17th RUNX transcription factors in development and disease, Hiroshima Japan July 2010. Oral

Coles, S.J., Wang, E., Mans, S., Burnett, A.K., Darley, R.L. and Tonks, A. (2010). The immunosuppressive protein, CD200, promotes natural killer dysfunction in acute myeloid leukaemia. Wales Cancer Conference, April 2010. Oral

Coles, S.J., Man, S., Wang, E., Burnett, A.K., Darley, R.L. and Tonks, A. (2009). The role of CD200 in AML tumour immunity. 16th RUNX transcription factors in development and disease, Oxford UK August 2009. Poster

Coles, S.J. Hancock, J., Hutson, S. and Conway, M.E. (2007)S-nitrosylation of the human branched chain aminotransferase isoenzymes.  UK 8th NO forum, Bradford, UK, Dec 2007. Oral

Coles, S.J., Hutson, S.M., Hancock, J. and Conway, M.E. (2006).  S-nitrosylation, redox regulation and the human branched chain aminotransferase (hBCATc).  Biochemical Society, Glasgow, UK, June 2006. Poster

Conway, M.E. Coles, S.J. Islam, M, Mallet, C. and Hutson, S.M. (2006).  The human branched chain aminotransferase (hBCATc) differs in sensitivity to peroxide compared to the mitochondrial isofrom.  Biochemical Society, Glasgow, UK, June 2006. Poster

 

Book Chapters

Chapter 10 in Redox Mediated Signal Transduction (2008). Springer (ISBN 978-1-58829-842-3), 136-152.

Professional bodies and committees

Professional bodies and committees

Chair of the ISE Health and Safety Committee
Member of the Genetically Modified Organisms Committee
Member of the Worcester Health Research Committee
Member of the University of Worcester Research Strategy Committee
Founding Member of the WBRG

 

Member of the British Society for Immunology