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Dr Allain Bueno

Senior Lecturer in Human Biology and Nutrition

Institute of Science & the Environment

Contact Details

email: a.bueno@worc.ac.uk

tel: 01905 54 2525

Dr Allain Bueno joined the University of Worcester in January 2012, after 4 years of Post-doctoral studies at the Institute of Brain Chemistry and Human Nutrition, London, working with Prof Michael Angus Crawford, one of the pioneers in fatty acid metabolism and brain composition.

Whilst in London, Dr Bueno focused on biochemical and neurophysiological hallmarks of disorders affecting the Central Nervous System, such as Down syndrome, Attention Deficit Hyperactivity Disorder, pre-eclampsia and neural disorders induced by obesity. Collaborative work included the Institute of Psychiatry, King's College London; Department of Child Psychiatry, Medical Academy of Warsaw; Faculty of Medicine, the University of Khartoum; the Masovian Centre for Neuropsychiatry and Rehabilitation for Children and Adolescents, Poland; and the Department of Nutritional Physiology, Sao Paulo Federal University.

Dr Bueno investigated in his PhD the effects of dietary fats on adipose tissue metabolism, and how different types of fat can influence disorders such as systemic inflammation and diabetes. In his MPhil Dr Bueno investigated the impact of surgical removal of fat pads on metabolic adaptations in obesity induced by diet and by neurochemical malfunctioning.

Dr Bueno holds strong experience in clinical sciences, having worked and taught in a leading Tertiary Referral Hospital. His current area of research includes the biochemistry of dietary fats and their role in oxidative stress and brain metabolism and function.

Teaching & Research

Teaching & Research

Taught modules

  • BIOS 1211 Biology of Disease
  • BIOS 2106 Systems Physiology I (Cardiovascular and Respiratory Physiology)
  • BIOS 3108 Systems Physiology II (Neurophysiology)
  • BIOS 3028 Human Nutrition and Disease Modulation
  • Award Leader for Human Biology

Research

Dr Bueno is a founding member of the Worcester Biomedical Research Group (WBRG) and is currently involved in several research projects.

Post-doctoral:

  • Dr Alex Wadley (PhD): ‘Validating a Novel Flow Cytometric Assay to Assess the Functional Consequence of Intracellular Thiol-Redox Status in Viable Peripheral Blood Mononuclear Cells: implications for AML anti-tumour immunity’ (as co-supervisor) 2014 – 2017  
  • Dr Rosangela Passos (PhD, RNutr): ‘The role of plant polyphenols in the pathogenesis and management of hepatic, metabolic and neural diseases’ (as Director of Studies) 2015-2016  

PhD Students:

  • Ms Jane Richardson: ‘The impact of a group intervention to improve nutritional intake and promote behaviour change for women who have had treatment for breast cancer’ (as co-supervisor).  
  • Ms Bruna Hirata: ‘The effects of plant polyphenol supplementation on cell membrane phospholipid composition of diet-induced obese rats: a lipidomic analysis’ (as co-supervisor).  
  • Ms Ellen Joyce: ‘The effects of plant polyphenols on anti-oxidant response and lipid stability in a model of neural degeneration” (as Director of Studies).

Funding and Awards since 2014

  • 2017: £48,000 – University of Worcester PhD studentship, Nutritional Neurosciences
  • 2017: €1,250 – ERASMUS Staff Teaching Mobility programme. Department of Biology, University of Turku, Finland
  • 2017: £26,000 – Sao Paulo Federal University PhD studentship, Nutritional Biochemistry
  • 2016: £1,200 – ERASMUS Staff Teaching Mobility programme. Faculty of Biochemistry and Genetics, University of Navarra, Spain
  • 2015: £38,900 – Bahia Federal University, Brazil, Postdoctoral Research Associate
  • 2015: £900 – ERASMUS Staff Teaching Mobility programme. Charles University, Czech Republic Prague
  • 2014: £91,328 – University of Worcester, Post-Doctoral Research Associate
  • 2014: £1,500 – University of Worcester, Institute of Science and the Environment Learning and Teaching Project
  • 2014: £800 – ERASMUS Staff Teaching Mobility programme Faculty of Pharmacy, Nutrition and Dietetics, University of Navarra, Spain       

External Collaborators

  • Dr Cristiane de Oliveira – Mayo Clinic, Phoenix, Arizona, USA
  • Prof Michael Crawford, PhD, FSB, FRCPath – Imperial College London
  • Dr Monica Telles – Sao Paulo Federal University, Brazil
  • Dr Rosangela Passos de Jesus – Bahia federal University, Brazil
  • Dr Pedro Gonzalez Muniesa – University of Navarra, Spain 

Research Interests

  • Dietary fats, the endocrine function of the adipose tissue and signalling to the brain
  • Cell membrane phospholipid composition in health and disease and its relation to nutritional status
  • Brain composition and function in conditions of increased oxidative stress
Professional Bodies

Professional Bodies

Registered Nutritionist. Association for Nutrition

Journal of Physiology and Biochemistry, Executive Editor

Publications

Publications

Publications

  1. Chao A, Waitzberg D, de Jesus RP, Bueno AA, Kha V, Allen K, Kappus M, Medici V. Malnutrition and Nutritional Support in Alcoholic Liver Disease: a Review. Curr Gastroenterol Rep. 2016 Dec;18(12):65.
  2. Dornellas AP, Watanabe RL, Pimentel GD, Boldarine VT, Nascimento CM, Oyama LM, Ghebremeskel K, Wang Y, Bueno AA, Ribeiro EB. Deleterious effects of lard-enriched diet on tissues fatty acids composition and hypothalamic insulin actions. Prostaglandins Leukot Essent Fatty Acids. 2015 Dec;102-103:21-9.
  3. Bueno AA, Brand A, Neville MM, Lehane C, Brierley N, Crawford MA. Erythrocyte phospholipid molecular species and fatty acids of Down syndrome children compared with non-affected siblings. Br J Nutr. 2014 Nov 24:1-10. [Epub ahead of print] PubMed PMID: 25418850.
  4. Gut microbiota, probiotics and diabetes. Gomes AC, Bueno AA, de Souza RG, Mota JF. Nutr J. 2014 Jun 17;13(1):60.
  5. Omega-3 fatty acids are inversely related to callous and unemotional traits in adolescent boys with attention deficit hyperactivity disorder. Gow RV, Vallee-Tourangeau F, Crawford MA, Taylor E, Ghebremeskel K, Bueno AA, Hibbeln JR, Sumich A, Rubia K. Prostaglandins Leukot Essent Fatty Acids. 2013 Jun;88(6):411-8.
  6. Omega-3 fatty acids are related to abnormal emotion processing in adolescent boys with attention deficit hyperactivity disorder. Gow RV, Sumich A, Vallee-Tourangeau F, Angus Crawford M, Ghebremeskel K, Bueno AA, Hibbeln JR, Taylor E, Wilson DA, Rubia K. Prostaglandins Leukot Essent Fatty Acids. 2013 Jun;88(6):419-29.
  7. Perturbations in Blood Phosphatidylcholine and Sphingomyelin Fatty Acid Composition in a Sample Population of Cigarette Smokers. Ionescu N, Freitas C, Bueno AA. Ind J Clin Biochem. 2013 Oct;28(4):361-7.
  8. Dimethyl acetals, an indirect marker of the endogenous antioxidant plasmalogen level, are reduced in blood lipids of Sudanese pre-eclamptic subjects whose background diet is high in carbohydrate. Bueno AA, Ghebremeskel K, Bakheit KH, Elbashir MI, Adam I. J Obstet Gynaecol. 2012 Apr;32(3):241-6.
  9. A palatable hyperlipidic diet causes obesity and affects brain glucose metabolism in rats. Estadella D, Oyama LM, Bueno AA, Habitante CA, Souza GI, Ribeiro EB, Motoyama CS, Oller do Nascimento CM. Lipids Health Dis. 2011 Sep 23;10:168.
  10. White adipose tissue re-growth after partial lipectomy in high fat diet induced obese wistar rats. Bueno AA, Habitante CA, Oyama LM, Estadella D, Ribeiro EB, Oller do Nascimento CM. J Physiol Sci. 2011 Jan;61(1):55-63.
  11. Fructose alters adiponectin, haptoglobin and angiotensinogen gene expression in 3T3-L1 adipocytes. Carvalho CR, Bueno AA, Mattos AM, Biz C, de Oliveira C, Pisani LP, Ribeiro EB, do Nascimento CM, Oyama LM. Nutr Res. 2010 Sep;30(9):644-9.
  12. Outcome of the Public consultation on the Draft Opinion on Dietary Reference Values for fats. Scientific Report of EFSA – European Food Safety Authority. Signatory. EFSA Journal 2010; 8(5):1507
  13. Exercise training in rats impairs the replenishment of white adipose tissue after partial lipectomy. Habitante CA, Oyama LM, Bueno AA, Ribeiro EB, Estadella D, Dâmaso AR, Nascimento CM. Eur J Appl Physiol. 2010 Jun;109(3):371-7.
  14. Long chain saturated fatty acids increase haptoglobin gene expression in C57BL/6J mice adipose tissue and 3T3-L1 cells. Bueno AA, Oyama LM, de Macedo Motoyama CS, da Silva Biz CR, Silveira VL, Ribeiro EB, Oller do Nascimento CM. Eur J Nutr. 2010 Jun;49(4):235-41.
  15. EU nutrition rule will deceive consumers. Letters to the Editor - The Times. Signatory. Published 30 September 2009.
  16. Hydrogenated fat diet intake during pregnancy and lactation modifies the PAI-1 gene expression in white adipose tissue of offspring in adult life. Pisani LP, Oller do Nascimento CM, Bueno AA, Biz C, Albuquerque KT, Ribeiro EB, Oyama LM. Lipids Health Dis. 2008 Apr 4;7:13.
  17. Hydrogenated fat intake during pregnancy and lactation modifies serum lipid profile and adipokine mRNA in 21-day-old rats. Pisani LP, Oyama LM, Bueno AA, Biz C, Albuquerque KT, Ribeiro EB, Oller do Nascimento CM. Nutrition. 2008 Mar;24(3):255-61.
  18. Effects of different fatty acids and dietary lipids on adiponectin gene expression in 3T3-L1 cells and C57BL/6J mice adipose tissue. Bueno AA, Oyama LM, de Oliveira C, Pisani LP, Ribeiro EB, Silveira VL, Oller do Nascimento CM. Pflugers Arch – European Journal of Physiology 2008 Jan;455(4):701-9.
  19. Lauric acid increases IL-6 and decreases adiponectin gene expression in human SGBS adipocytes. Bueno AA, Nascimento CMO, Hunter L, Trayhurn P. International Journal of Obesity, Nature Publishing Group. 2008; 32:S58.
  20. PAI-1 adipose tissue gene expression in obesity may be linked with thyroid hormones. Oller Do Nascimento C; Biz C; Oliveira C; Bueno AA, Mattos A, Oyama L. International Journal Of Obesity, Nature Publishing Group. 2007; 31:S66.
  21. Effects of fatty acids and glucocorticoids on the adiponectin gene expression. De Oliveira C, Bueno AA, Oyama LM, Do Nascimento CO. Annals of Nutrition and Metabolism, Karger Allschwilerstrasse Switzerland. 2007; 51:226
  22. Intake of trans fatty acid-rich hydrogenated fat diet during pregnancy and lactation altered litter metabolism and adiponectin gene expression. Oller Do Nascimento C, Pisani L, Bueno AA, Albuquerque K, Carvalho C, Tavares do Carmo MG. International Journal Of Obesity, Nature Publishing Group. 2007; 31:S139.
  23. Lipid metabolism of monosodium glutamate obese rats after partial removal of adipose tissue. Bueno AA, Oyama LM, Estadella D, Habitante CA, Bernardes BS, Ribeiro EB, Oller Do Nascimento CM. Physiol Res. 2005;54(1):57-65.
  24. Bueno AA, Oyama LM, Ribeiro EB, Nascimento CMO. Efeito da lipectomia sobre o metabolism do tecido adiposo de ratos obesos. Jornal da Paulista. 2004; 176(1): 11-15.
  25. Palatable hyperlipidic diet causes obesity and affects rats' brain glucose metabolism. Estadella D, Oyama LM, Habitante CA, Bernardes BSS, Bueno AA, do Nascimento CO. International Journal Of Obesity, Nature Publishing Group. 2004; 28: S80
  26. Bueno AA, Nascimento CMO. Efeito da lipectomia sobre o metabolismo do tecido adipose de ratos tornados obesos por dieta de cafeteria. Revista Ciencia Hoje. 2003 Sep; 197(1): 50-51. ISSN: 0101-8515
  27. Tubular urinary enzymes in acute post-infectious glomerulonephritis. Naghettini AV, Nogueira PC, Juliano M, Bueno AA, Casarini DE, de Abreu Carvalhaes JT. Pediatr Nephrol. 2001 Sep;16(9):719-22.

Chapters of Books:

  1. Capítulo 165: Flavonóides e Resveratrol na prevenção e tratamento de doenças crônicas não transmissíveis (Chapter 165: Flavonoids and resveratrol in the prevention and treatment of non-communicable chronic diseases). In: Nutrição Oral, Enteral e Parenteral na Prática Clínica, 5th Edition. Dan L Waitzberg (Waitzberg D). 3296 pages. Editora Atheneu Publishers, Sao Paulo, Brazil. ISBN: 9788538807933
  2. Funcao endocrina do tecido adiposo (The endocrine function of adipose tissue). In: Obesidade. Ana Damaso (Damaso AR). Medsi Medical Publishers, Sao Paulo, Brazil. ISBN: 8571993521.
  3. O pancreas endocrino (The endocrine pancreas). In: Fisiologia Endocrina. Eliane Beraldi Ribeiro (Ribeiro EB). Editora Manole Publishers, Rio de Janeiro, Brazil. ISBN: 9788520426609
  4. O Papel secretor do tecido adiposo (The endocrine role of the adipose tissue). In: Fisiologia Endocrina. Eliane Beraldi Ribeiro (Ribeiro EB). Editora Manole Publishers, Rio de Janeiro, Brazil. ISBN: 9788520426609

Selected short communications:

  1. Estadella D, Pisani LP, Oyama LM, Bueno AA, Oller do Nascimento CM. Palatable high fat diet modifies the adipose tissue metabolism in rats with respect to the age and the treatment time. T3:S17:25. In: The XIII International Congress on Obesity (ICO), 1st - 4th May 2016, Vancouver, Canada. Obesity Reviews.
  2. 2nd Research on Ageing Forum. Keele University, UK. April 2014
  3. 29th Ernst Klenk Symposium in Molecular Medicine – Systems Approaches in Translational Medicine. Cologne, Germany. October 2013
  4. 20th European Congress on Obesity (ECO2013). Liverpool, UK May 2013
  5. 27th Ernst Klenk Symposium in Molecular Medicine – Lipid metabolic diseases. October 2011 Cologne, Germany. Special participation of Prof Joseph Goldstein and Prof Michael Brown (1985 Nobel Prize winners) presenting the Ernst Klenk Lecture ‘Surviving Starvation: Essential Role of the Ghrelin-Growth Hormone Axis’.
  6. 9th Scientific Meeting of the International Society for the Study of Fatty Acids and Lipids (ISSFAL 2010), Maastricht, the Netherlands.
  7. Fatty Acids and Neurodevelopmental Disorders Meeting (FAND 2009). Madgalen College, University of Oxford, Oxford, UK .
  8. 10th World Down Syndrome Congress, 2009, Dublin, Ireland.
  9. 16th European Congress on Obesity (ECO 2008). Geneva, Switzerland.
  10. 15th European Congress on Obesity (ECO 2007). Budapest, Hungary.
  11. 14th Latin American Congress on Nutrition (SLAN 2006). Florianopolis, Brazil.
  12. 10th International Congress on Obesity (ICO 2006). Sydney, Australia.
  13. 41st Congress of the Brazilian Physiological Society, 2006. Ribeirao Preto, Brazil.
  14. 14th European Congress on Obesity (ECO 2005). Athens, Greece.
  15. 13th European Congress on Obesity (ECO 2004). Prague, Czech Republic.
  16. 21st Conference of the Latin American Association of Physiological Sciences (ALACF 2003). Ribeirao Preto, Brazil.
  17. 9th International Congress on Obesity (ICO 2002). Sao Paulo, Brazil.
  18. 17th International Congress of Nutrition (ICN 2001). Vienna, Austria.
  19. 11th International Congress of Endocrinology (ICE 2000). Sydney, Australia
Qualifications

Qualifications

Advanced Course in Dietary Assessment Methods, The University of Aberdeen. Endorsed by the Association for Nutrition and by the British Dietetic Association

Fellow of the Higher Education Academy

PGCert Learning and teaching in Higher Education (University of Worcester, 2014).

Phlebotomy certification. Ashford and St. Peter's Hospitals NHS Trust, London

Ph.D. Human Nutrition (Sao Paulo Federal University, 2007). Visiting Research Student, Neuroendocrine & Obesity Biology Research Unit, University of Liverpool

M.Phil. Nutritional Physiology (Sao Paulo Federal University, 2003)

BSc Biomedical Science 1st Class Hons (Sao Paulo Federal University, 2000)