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Dr Alex Wadley

Post-Doctoral Researcher/Lecturer in Biomedical Sciences

Institute of Science & the Environment

Contact Details

email: a.wadley@worc.ac.uk

tel: 01905 542720

Room EE G081

Qualifications

PhD: Investigating changes in markers of oxidative stress and inflammation in response to exercise, University of Birmingham (2010 – 2013)
PG Cert in Learning & Teaching in Higher Education, University of Birmingham (2012)
BSc: Sport & Exercise Sciences, University of Birmingham (2006-2009)

Teaching

Teaching

Introduction to Biological Chemistry & Genetics
Molecular Cell Biology
Project and Career Development
Applied Human Metabolisms
Human Systems Physiology Two

Research

Research

Alex joined the institute in October 2014 following Doctoral studies at the University of Birmingham and a Post-Doctoral position at Loughborough University. He is appointed as a Post-Doctoral Researcher & Lecturer in Biomedical Sciences, working alongside Dr Steven Coles, Dr Allain Bueno and Ian Callow in the Worcester Biomedical Research Group (WBRG). Alex’s work with Dr Steven Coles focusses on protein thiol oxidation in patients suffering from acute myeloid leukaemia (AML). Using highly specialised assays, WBRG is exploring global and specific protein oxidation spectra in primary AML cancer cells. The aim of this research is to explore the mechanisms explaining how oxidative stress modulates the cell cycle of AML cancer cells. Alex and Dr Allain Bueno’s research focusses on nutritional interventions to modulate cell membrane phospholipid composition and subsequent impact on cellular oxidative stress. This work will explore individual variability in responses to essential fatty acid supplementation and consequences for human health, particularly in age-associated neurological disorders.

Dr Wadley’s background is in Sport and Exercise Science. During his PhD, Alex investigated changes in oxidative stress and inflammation in response to exercise in a variety of populations; from trained athletes to patients suffering with rheumatoid arthritis. Alex is currently collaborating with the Institute of Sport and Exercise Sciences at the University of Worcester to investigate how genetic factors influence weight loss changes with exercise. Alex also maintains strong collaborative links with the University of Birmingham and the Translational Chemical Biology Research Group at Loughborough University.

Professional Bodies

Professional Bodies

Member of the Biochemical Society
Member the European College of Sport & Exercise Sciences
Member of the American College of Sports Medicine
Member of the Society for the Study of Human Biology

Publications

Publications

Published Articles

  • Wadley, A.J., Svendsen, I,S., and Gleeson, M. (2016). Heightened exercise-induced oxidative stress at simulated moderate altitude vs. sea level in trained cyclists. Int J Sport Nutr Exerc Metab (In Press)
  • Turner, J.E., Spielmann G., Wadley, A.J., Fisher, J.P., Aldred, S., Simpson, R.J., Campbell, J.P. (2016). Exercise-induced B lymphocyte mobilisation: evidence for an influx of immature cells into the bloodstream in humans, Journal of Physiology & Behaviour (In Press)
  • Turner, J.E., Wadley, A.J., Fisher, J.P., Bosch, J.A, Aldred, S., Drayson, M.T., & Campbell, J.P.  (2016). Intensive exercise does not preferentially mobilize skin-homing T cells and NK cells, Med Sci Sport & Ex (In Press)
  • Wadley, A.J., Morgan, R.G., Darley R,L., Hole, P.S., & Coles, S.J. (2016). Using Flow Cytometry to Detect and Measure Intracellular Thiol Redox Status in Viable T cells from Heterogeneous Populations. Methods in Molecular Biology (In Press)
  • Wadley, A.J., Turner, J.E. and Aldred, S. (2016). Factors influencing post-exercise plasma protein carbonyl concentration, Free Radical Research, 12, 1-10
  • Wadley, A.J., Aldred, S., Coles, S.J. (2016). An unexplored role for Peroxiredoxin in exercise-induced redox signalling? Redox Biology, 8, 51-58.
  • Wadley, A.J., Chen, Y.W., Lip, G.Y.H., Fisher, J.P., & Aldred, S. (2015). Low volume-high intensity interval exercise elicits anti-oxidant and anti-inflammatory effects in humans, Journal of Sports Sciences, 34(1), 1-9
  • Wadley, A.J., Svendsen, I,S., Killer, S. C., and Gleeson, M. (2015). The impact of intensified training with a high or moderate carbohydrate feeding strategy on resting and exercise-induced oxidative stress, European Journal of Applied Physiology, 115(8), 1757-67
  • Wadley, A.J., Chen, Y.W., Bennett, S.J., Lip, G.Y.H., Turner, J.E., Fisher, J.P., & Aldred, S. (2015). Monitoring changes in Thioredoxin and over-oxidised Peroxiredoxin in response to exercise in humans, Free Radical Research, 49(3), 290-98
  • Wadley, A.J., Veldhuijzen van Zanten, J.C.C.S., Stavropoulos-Kalinoglou, A., Metsios, G., Smith, J., Kitas, G, & Aldred, S. (2014). Three months of moderate-intensity exercise reduced plasma 3-nitrotyrosine levels in rheumatoid arthritis patients, European Journal of Applied Physiology, 114(7), 1483-92
  • Wadley, A.J., Veldhuijzen van Zanten, J.C.C.S., Paine, N.J., Drayson, M.T., & Aldred, S. (2014). Underlying inflammation has no impact on the oxidative stress response to acute mental stress. Brain, Behaviour & Immunity, 40, 182-90
  • Paine, N.J., Ring, C., Aldred, A., Bosch, J.A., Wadley, A.J., & Veldhuijzen van Zanten, J.C.C.S. (2013). Eccentric-exercise induced inflammation attenuates the vascular responses to mental stress. Brain, Behaviour and Immunity, 30, 133-142
  • Wadley, A.J., Veldhuijzen van Zanten, J.J.C.S, & Aldred, S. (2013). The interactions of oxidative stress and inflammation with vascular dysfunction in ageing?: the vascular health triad. American Association of Ageing, 35, 705-718

 

Conference Presentations

  • Wadley, A.J., Wilson, L., Mastana, S. and Lindley, M.R. (2015). The potential of omega-3 polyunsaturated fatty acids to suppress post-exercise oxidative stress and inflammation. International Congress on Comparative Physiology and Biochemistry, Krakow, Poland.
  • Lindley, M.R. Wadley, A.J., Wilson, L., Mastana, S. (2015). The physiology and biochemistry of omega-3 polyunsaturated fatty acids and their bioactive derivatives. International Congress on Comparative Physiology and Biochemistry, Krakow, Poland.
  • Wilson, L., Wadley, A.J., Mickleborough, T.D., Mastana, S. Lindley, M.R. (2015). Fish Oil Supplementation and Cycling Time Trial Performance. American College of Sports Medicine, San Diego, California, US.
  • Wadley, A.J., Chen, Y.W., Bennett, S.J., Lip, G.Y.H., Turner, J.E., Fisher, J.P., & Aldred, S. (2015). High intensity exercise transiently increased over-oxidised Peroxiredoxin and Thioredoxin protein expression in humans. Metabolic Drivers of Immunity, Aston, Birmingham, UK.
  • Wadley, A.J., Fisher, J.P., Lip, G.Y.H., Chen, Y.W., & Aldred, S. (2014). Comparison of LV-HIIT and steady state exercise bouts on oxidative stress and inflammation in humans. Role of inflammation in exercise, health and disease. American College of Sports Medicine, Orlando, Florida, US.
  • Wadley, A.J., Fisher, J.P., Lip, G.Y.H., Chen, Y.W., & Aldred, S. (2014). Thioredoxin and over-oxidised peroxiredoxin are increased in peripheral blood mononuclear cells during exercise in humans. Redox regulation in health and disease: a 50 year history. Biochemistry Society, Edinburgh, UK.
  • Campbell, J.P., Turner, J.E., Bosch, J.A., Wadley, A.J, Drayson, M.T., and Aldred. S. (2014). Exercise mobilises skin-homing effector CD8+ T cells and natural killer cells into peripheral blood.  International Society of Exercise Immunology, Newcastle, Australia.
  • Wadley, A.J., Fisher, J.P., Chen, Y.W., & Aldred, S. (2013). Low volume high intensity interval and steady state exercise bouts elicit similar alterations in plasma markers of oxidative stress. 18th annual congress of the European College of Sport & Exercise Science, Barcelona, Spain.